{
  "Reactome": {
    "L4_very_high": {
      "n_genes": 378,
      "top_features": [
        [
          "R-HSA-8953854:Metabolism of RNA",
          212
        ],
        [
          "R-HSA-392499:Metabolism of proteins",
          165
        ],
        [
          "R-HSA-72766:Translation",
          147
        ],
        [
          "R-HSA-9824446:Viral Infection Pathways",
          112
        ],
        [
          "R-HSA-5663205:Infectious disease",
          112
        ],
        [
          "R-HSA-1643685:Disease",
          112
        ],
        [
          "R-HSA-72312:rRNA processing",
          100
        ],
        [
          "R-HSA-8868773:rRNA processing in the nucleus and cytosol",
          100
        ],
        [
          "R-HSA-6791226:Major pathway of rRNA processing in the nucleolus and cytosol",
          99
        ],
        [
          "R-HSA-72203:Processing of Capped Intron-Containing Pre-mRNA",
          91
        ],
        [
          "R-HSA-72172:mRNA Splicing",
          78
        ],
        [
          "R-HSA-72163:mRNA Splicing - Major Pathway",
          71
        ],
        [
          "R-HSA-5368287:Mitochondrial translation",
          71
        ],
        [
          "R-HSA-5389840:Mitochondrial translation elongation",
          70
        ],
        [
          "R-HSA-9937383:Mitochondrial ribosome-associated quality control",
          68
        ],
        [
          "R-HSA-5368286:Mitochondrial translation initiation",
          67
        ],
        [
          "R-HSA-5419276:Mitochondrial translation termination",
          67
        ],
        [
          "R-HSA-9839923:Dengue Virus Infection",
          52
        ],
        [
          "R-HSA-72613:Eukaryotic Translation Initiation",
          51
        ],
        [
          "R-HSA-72737:Cap-dependent Translation Initiation",
          51
        ]
      ]
    },
    "L1_low": {
      "n_genes": 536,
      "top_features": [
        [
          "R-HSA-1643685:Disease",
          181
        ],
        [
          "R-HSA-1430728:Metabolism",
          148
        ],
        [
          "R-HSA-162582:Signal Transduction",
          146
        ],
        [
          "R-HSA-74160:Gene expression (Transcription)",
          140
        ],
        [
          "R-HSA-168256:Immune System",
          129
        ],
        [
          "R-HSA-392499:Metabolism of proteins",
          128
        ],
        [
          "R-HSA-1640170:Cell Cycle",
          114
        ],
        [
          "R-HSA-73857:RNA Polymerase II Transcription",
          110
        ],
        [
          "R-HSA-8953897:Cellular responses to stimuli",
          107
        ],
        [
          "R-HSA-5663205:Infectious disease",
          106
        ],
        [
          "R-HSA-212436:Generic Transcription Pathway",
          104
        ],
        [
          "R-HSA-2262752:Cellular responses to stress",
          100
        ],
        [
          "R-HSA-9824446:Viral Infection Pathways",
          93
        ],
        [
          "R-HSA-597592:Post-translational protein modification",
          90
        ],
        [
          "R-HSA-69278:Cell Cycle, Mitotic",
          86
        ],
        [
          "R-HSA-8953854:Metabolism of RNA",
          81
        ],
        [
          "R-HSA-1266738:Developmental Biology",
          76
        ],
        [
          "R-HSA-168249:Innate Immune System",
          69
        ],
        [
          "R-HSA-1280218:Adaptive Immune System",
          65
        ],
        [
          "R-HSA-73894:DNA Repair",
          64
        ]
      ]
    },
    "L0_no_annotation": {
      "n_genes": 317,
      "top_features": []
    }
  },
  "HGNC_gene_group": {
    "L4_very_high": {
      "n_genes": 313,
      "top_features": [
        [
          "Mitochondrial ribosomal proteins",
          66
        ],
        [
          "MicroRNA protein coding host genes",
          58
        ],
        [
          "Small nucleolar RNA protein coding host genes",
          43
        ],
        [
          "Large subunit mitochondrial ribosomal proteins",
          40
        ],
        [
          "WD repeat domain containing",
          35
        ],
        [
          "L ribosomal proteins",
          32
        ],
        [
          "Armadillo like helical domain containing",
          30
        ],
        [
          "RNA binding motif containing",
          27
        ],
        [
          "S ribosomal proteins",
          23
        ],
        [
          "Small subunit mitochondrial ribosomal proteins",
          20
        ],
        [
          "Mediator complex",
          17
        ],
        [
          "SSU processome",
          14
        ],
        [
          "RNA polymerase subunits",
          13
        ],
        [
          "Ribosomal biogenesis factors",
          10
        ],
        [
          "DEAD-box helicases",
          4
        ],
        [
          "Eukaryotic translation initiation factor 3",
          4
        ],
        [
          "Spliceosomal C complex",
          4
        ],
        [
          "Nucleoporins",
          3
        ],
        [
          "Spliceosomal A complex",
          3
        ],
        [
          "Aminoacyl tRNA synthetases, Class I",
          3
        ]
      ]
    },
    "L1_low": {
      "n_genes": 772,
      "top_features": [
        [
          "Mitochondrial respiratory chain complex assembly factors",
          12
        ],
        [
          "Ribosomal biogenesis factors",
          12
        ],
        [
          "Aminoacyl tRNA synthetases, Class II",
          9
        ],
        [
          "RNase MRP complex subunits",
          9
        ],
        [
          "Dynactin subunits",
          8
        ],
        [
          "AAA ATPases",
          8
        ],
        [
          "Myb/SANT domain containing",
          8
        ],
        [
          "Tip60/Nua4 histone acetyltransferase complex subunits",
          8
        ],
        [
          "Nuclear RNase P complex subunits",
          8
        ],
        [
          "Nucleotide excision repair",
          8
        ],
        [
          "SRCAP complex subunits",
          7
        ],
        [
          "Ring finger proteins",
          7
        ],
        [
          "FA complementation groups",
          7
        ],
        [
          "COP9 signalosome",
          7
        ],
        [
          "Flavoproteins",
          7
        ],
        [
          "SH2 domain containing",
          7
        ],
        [
          "Prefoldin subunits",
          7
        ],
        [
          "Proteasome",
          7
        ],
        [
          "DNA/RNA methyltransferases",
          7
        ],
        [
          "Chaperonin containing TCP1",
          6
        ]
      ]
    },
    "L0_no_annotation": {
      "n_genes": 246,
      "top_features": []
    }
  },
  "GO_BP": {
    "L4_very_high": {
      "n_genes": 429,
      "top_features": [
        [
          "GO:0006412:translation",
          108
        ],
        [
          "GO:0032543:mitochondrial translation",
          68
        ],
        [
          "GO:0006357:regulation of transcription by RNA polymerase II",
          65
        ],
        [
          "GO:0000398:mRNA splicing, via spliceosome",
          58
        ],
        [
          "GO:0002181:cytoplasmic translation",
          53
        ],
        [
          "GO:0045893:positive regulation of DNA-templated transcription",
          52
        ],
        [
          "GO:0045944:positive regulation of transcription by RNA polymerase II",
          48
        ],
        [
          "GO:0042274:ribosomal small subunit biogenesis",
          44
        ],
        [
          "GO:0006355:regulation of DNA-templated transcription",
          43
        ],
        [
          "GO:0006364:rRNA processing",
          34
        ],
        [
          "GO:0051123:RNA polymerase II preinitiation complex assembly",
          30
        ],
        [
          "GO:0007283:spermatogenesis",
          30
        ],
        [
          "GO:1901740:negative regulation of myoblast fusion",
          30
        ],
        [
          "GO:0006941:striated muscle contraction",
          30
        ],
        [
          "GO:0030490:maturation of SSU-rRNA",
          29
        ],
        [
          "GO:0000122:negative regulation of transcription by RNA polymerase II",
          29
        ],
        [
          "GO:0006396:RNA processing",
          29
        ],
        [
          "GO:0060261:positive regulation of transcription initiation by RNA polymerase II",
          27
        ],
        [
          "GO:0006366:transcription by RNA polymerase II",
          24
        ],
        [
          "GO:0008380:RNA splicing",
          23
        ]
      ]
    },
    "L1_low": {
      "n_genes": 616,
      "top_features": [
        [
          "GO:0043066:negative regulation of apoptotic process",
          25
        ],
        [
          "GO:0006886:intracellular protein transport",
          16
        ],
        [
          "GO:0006413:translational initiation",
          16
        ],
        [
          "GO:0006508:proteolysis",
          15
        ],
        [
          "GO:0010629:negative regulation of gene expression",
          15
        ],
        [
          "GO:0045944:positive regulation of transcription by RNA polymerase II",
          14
        ],
        [
          "GO:0000278:mitotic cell cycle",
          14
        ],
        [
          "GO:0035556:intracellular signal transduction",
          14
        ],
        [
          "GO:0007005:mitochondrion organization",
          14
        ],
        [
          "GO:0034976:response to endoplasmic reticulum stress",
          13
        ],
        [
          "GO:0007165:signal transduction",
          13
        ],
        [
          "GO:0006468:protein phosphorylation",
          12
        ],
        [
          "GO:0030036:actin cytoskeleton organization",
          12
        ],
        [
          "GO:0016236:macroautophagy",
          12
        ],
        [
          "GO:0006487:protein N-linked glycosylation",
          12
        ],
        [
          "GO:0016192:vesicle-mediated transport",
          11
        ],
        [
          "GO:0006974:DNA damage response",
          11
        ],
        [
          "GO:0002183:cytoplasmic translational initiation",
          11
        ],
        [
          "GO:0006418:tRNA aminoacylation for protein translation",
          10
        ],
        [
          "GO:0055085:transmembrane transport",
          10
        ]
      ]
    },
    "L0_no_annotation": {
      "n_genes": 50,
      "top_features": []
    }
  },
  "GO_MF": {
    "L4_very_high": {
      "n_genes": 424,
      "top_features": [
        [
          "GO:0005515:protein binding",
          397
        ],
        [
          "GO:0003723:RNA binding",
          183
        ],
        [
          "GO:0003735:structural constituent of ribosome",
          80
        ],
        [
          "GO:0003676:nucleic acid binding",
          28
        ],
        [
          "GO:0003677:DNA binding",
          18
        ],
        [
          "GO:0042802:identical protein binding",
          16
        ],
        [
          "GO:0003729:mRNA binding",
          12
        ],
        [
          "GO:0003713:transcription coactivator activity",
          7
        ],
        [
          "GO:0030674:protein-macromolecule adaptor activity",
          7
        ],
        [
          "GO:0008270:zinc ion binding",
          7
        ],
        [
          "GO:0003712:transcription coregulator activity",
          6
        ],
        [
          "GO:0003682:chromatin binding",
          6
        ],
        [
          "GO:0045296:cadherin binding",
          5
        ],
        [
          "GO:0008017:microtubule binding",
          5
        ],
        [
          "GO:0019901:protein kinase binding",
          4
        ],
        [
          "GO:0046982:protein heterodimerization activity",
          4
        ],
        [
          "GO:0003743:translation initiation factor activity",
          4
        ],
        [
          "GO:0019899:enzyme binding",
          3
        ],
        [
          "GO:0003924:GTPase activity",
          3
        ],
        [
          "GO:0019843:rRNA binding",
          3
        ]
      ]
    },
    "L1_low": {
      "n_genes": 486,
      "top_features": [
        [
          "GO:0005515:protein binding",
          404
        ],
        [
          "GO:0003723:RNA binding",
          70
        ],
        [
          "GO:0005524:ATP binding",
          68
        ],
        [
          "GO:0042802:identical protein binding",
          63
        ],
        [
          "GO:0003677:DNA binding",
          47
        ],
        [
          "GO:0019901:protein kinase binding",
          35
        ],
        [
          "GO:0019899:enzyme binding",
          31
        ],
        [
          "GO:0008270:zinc ion binding",
          28
        ],
        [
          "GO:0042803:protein homodimerization activity",
          28
        ],
        [
          "GO:0003676:nucleic acid binding",
          26
        ],
        [
          "GO:0003682:chromatin binding",
          26
        ],
        [
          "GO:0016887:ATP hydrolysis activity",
          24
        ],
        [
          "GO:0000166:nucleotide binding",
          23
        ],
        [
          "GO:0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding",
          19
        ],
        [
          "GO:0004672:protein kinase activity",
          18
        ],
        [
          "GO:0045296:cadherin binding",
          18
        ],
        [
          "GO:0044877:protein-containing complex binding",
          18
        ],
        [
          "GO:0140297:DNA-binding transcription factor binding",
          18
        ],
        [
          "GO:0000049:tRNA binding",
          17
        ],
        [
          "GO:0031625:ubiquitin protein ligase binding",
          17
        ]
      ]
    },
    "L0_no_annotation": {
      "n_genes": 32,
      "top_features": []
    }
  },
  "GO_CC": {
    "L4_very_high": {
      "n_genes": 470,
      "top_features": [
        [
          "GO:0005634:nucleus",
          347
        ],
        [
          "GO:0005737:cytoplasm",
          275
        ],
        [
          "GO:0005654:nucleoplasm",
          267
        ],
        [
          "GO:0005829:cytosol",
          221
        ],
        [
          "GO:0005730:nucleolus",
          101
        ],
        [
          "GO:0016020:membrane",
          87
        ],
        [
          "GO:0005739:mitochondrion",
          66
        ],
        [
          "GO:0070062:extracellular exosome",
          55
        ],
        [
          "GO:0005694:chromosome",
          32
        ],
        [
          "GO:0016607:nuclear speck",
          32
        ],
        [
          "GO:0032991:protein-containing complex",
          26
        ],
        [
          "GO:0000785:chromatin",
          25
        ],
        [
          "GO:0005759:mitochondrial matrix",
          23
        ],
        [
          "GO:0005886:plasma membrane",
          19
        ],
        [
          "GO:0016604:nuclear body",
          16
        ],
        [
          "GO:0005681:spliceosomal complex",
          16
        ],
        [
          "GO:0032040:small-subunit processome",
          16
        ],
        [
          "GO:0005576:extracellular region",
          15
        ],
        [
          "GO:0005840:ribosome",
          15
        ],
        [
          "GO:0022626:cytosolic ribosome",
          15
        ]
      ]
    },
    "L1_low": {
      "n_genes": 503,
      "top_features": [
        [
          "GO:0005634:nucleus",
          206
        ],
        [
          "GO:0005829:cytosol",
          196
        ],
        [
          "GO:0005654:nucleoplasm",
          180
        ],
        [
          "GO:0005737:cytoplasm",
          176
        ],
        [
          "GO:0016020:membrane",
          127
        ],
        [
          "GO:0005886:plasma membrane",
          89
        ],
        [
          "GO:0070062:extracellular exosome",
          87
        ],
        [
          "GO:0005739:mitochondrion",
          71
        ],
        [
          "GO:0005813:centrosome",
          67
        ],
        [
          "GO:0005789:endoplasmic reticulum membrane",
          55
        ],
        [
          "GO:0005783:endoplasmic reticulum",
          49
        ],
        [
          "GO:0032991:protein-containing complex",
          48
        ],
        [
          "GO:0005856:cytoskeleton",
          40
        ],
        [
          "GO:0005743:mitochondrial inner membrane",
          39
        ],
        [
          "GO:0005576:extracellular region",
          38
        ],
        [
          "GO:0005730:nucleolus",
          37
        ],
        [
          "GO:0005694:chromosome",
          36
        ],
        [
          "GO:0000139:Golgi membrane",
          35
        ],
        [
          "GO:0005765:lysosomal membrane",
          34
        ],
        [
          "GO:0005794:Golgi apparatus",
          33
        ]
      ]
    },
    "L0_no_annotation": {
      "n_genes": 18,
      "top_features": []
    }
  },
  "WikiPathways": {
    "L4_very_high": {
      "n_genes": 254,
      "top_features": [
        [
          "Cytoplasmic ribosomal proteins%WikiPathways_20260510%WP477%Homo sapiens",
          56
        ],
        [
          "mRNA processing%WikiPathways_20260510%WP411%Homo sapiens",
          46
        ],
        [
          "22q11 2 distal CNV%WikiPathways_20260510%WP5546%Homo sapiens",
          40
        ],
        [
          "miR targeted genes in lymphocytes%WikiPathways_20260510%WP2004%Homo sapiens",
          33
        ],
        [
          "RNA polymerase II transcription the preinitiation complex%WikiPathways_20260510%WP5563%Homo sapiens",
          33
        ],
        [
          "Ciliary landscape%WikiPathways_20260510%WP4352%Homo sapiens",
          26
        ],
        [
          "miR targeted genes in muscle cell%WikiPathways_20260510%WP2005%Homo sapiens",
          25
        ],
        [
          "Cell cycle%WikiPathways_20260510%WP179%Homo sapiens",
          19
        ],
        [
          "VEGFA VEGFR2 signaling%WikiPathways_20260510%WP3888%Homo sapiens",
          19
        ],
        [
          "Eukaryotic transcription initiation%WikiPathways_20260510%WP405%Homo sapiens",
          15
        ],
        [
          "Electron transport chain OXPHOS system in mitochondria%WikiPathways_20260510%WP111%Homo sapiens",
          15
        ],
        [
          "DNA replication%WikiPathways_20260510%WP466%Homo sapiens",
          14
        ],
        [
          "Oxidative phosphorylation%WikiPathways_20260510%WP623%Homo sapiens",
          13
        ],
        [
          "miR targeted genes in squamous cell%WikiPathways_20260510%WP2006%Homo sapiens",
          12
        ],
        [
          "G1 to S cell cycle control%WikiPathways_20260510%WP45%Homo sapiens",
          12
        ],
        [
          "Retinoblastoma gene in cancer%WikiPathways_20260510%WP2446%Homo sapiens",
          12
        ],
        [
          "Prader Willi and Angelman syndrome%WikiPathways_20260510%WP3998%Homo sapiens",
          11
        ],
        [
          "Nonalcoholic fatty liver disease%WikiPathways_20260510%WP4396%Homo sapiens",
          10
        ],
        [
          "Pyrimidine metabolism%WikiPathways_20260510%WP4022%Homo sapiens",
          8
        ],
        [
          "Mitochondrial complex I assembly model OXPHOS system%WikiPathways_20260510%WP4324%Homo sapiens",
          8
        ]
      ]
    },
    "L1_low": {
      "n_genes": 424,
      "top_features": [
        [
          "VEGFA VEGFR2 signaling%WikiPathways_20260510%WP3888%Homo sapiens",
          33
        ],
        [
          "Cancer pathways%WikiPathways_20260510%WP5434%Homo sapiens",
          25
        ],
        [
          "Pleural mesothelioma%WikiPathways_20260510%WP5087%Homo sapiens",
          24
        ],
        [
          "PI3K Akt signaling%WikiPathways_20260510%WP4172%Homo sapiens",
          20
        ],
        [
          "Disorders of mitochondrial homeostatis dynamics protein import and quality control%WikiPathways_20260510%WP5504%Homo sapiens",
          19
        ],
        [
          "Fragile X syndrome%WikiPathways_20260510%WP4549%Homo sapiens",
          17
        ],
        [
          "Translation factors%WikiPathways_20260510%WP107%Homo sapiens",
          17
        ],
        [
          "EGF EGFR signaling%WikiPathways_20260510%WP437%Homo sapiens",
          16
        ],
        [
          "Focal adhesion%WikiPathways_20260510%WP306%Homo sapiens",
          16
        ],
        [
          "Gastrin signaling%WikiPathways_20260510%WP4659%Homo sapiens",
          15
        ],
        [
          "Brain derived neurotrophic factor BDNF signaling%WikiPathways_20260510%WP2380%Homo sapiens",
          15
        ],
        [
          "Focal adhesion PI3K Akt mTOR signaling%WikiPathways_20260510%WP3932%Homo sapiens",
          15
        ],
        [
          "Insulin signaling%WikiPathways_20260510%WP481%Homo sapiens",
          14
        ],
        [
          "Circadian rhythm genes%WikiPathways_20260510%WP3594%Homo sapiens",
          13
        ],
        [
          "Leptin signaling%WikiPathways_20260510%WP2034%Homo sapiens",
          13
        ],
        [
          "Nuclear receptors meta pathway%WikiPathways_20260510%WP2882%Homo sapiens",
          13
        ],
        [
          "BDNF signaling in neurodevelopment%WikiPathways_20260510%WP5541%Homo sapiens",
          12
        ],
        [
          "Regulation of actin cytoskeleton%WikiPathways_20260510%WP51%Homo sapiens",
          12
        ],
        [
          "7q11 23 copy number variation syndrome%WikiPathways_20260510%WP4932%Homo sapiens",
          12
        ],
        [
          "Interferon type I signaling%WikiPathways_20260510%WP585%Homo sapiens",
          12
        ]
      ]
    },
    "L0_no_annotation": {
      "n_genes": 725,
      "top_features": []
    }
  },
  "KEGG": {
    "L4_very_high": {
      "n_genes": 297,
      "top_features": [
        [
          "Ribosome - Homo sapiens (human)",
          125
        ],
        [
          "Coronavirus disease - Homo sapiens (human)",
          62
        ],
        [
          "Amyotrophic lateral sclerosis - Homo sapiens (human)",
          56
        ],
        [
          "Spliceosome - Homo sapiens (human)",
          54
        ],
        [
          "Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)",
          44
        ],
        [
          "Alzheimer disease - Homo sapiens (human)",
          44
        ],
        [
          "Huntington disease - Homo sapiens (human)",
          43
        ],
        [
          "Parkinson disease - Homo sapiens (human)",
          43
        ],
        [
          "Prion disease - Homo sapiens (human)",
          39
        ],
        [
          "Thermogenesis - Homo sapiens (human)",
          32
        ],
        [
          "Ribosome biogenesis in eukaryotes - Homo sapiens (human)",
          32
        ],
        [
          "Metabolic pathways - Homo sapiens (human)",
          31
        ],
        [
          "Oxidative phosphorylation - Homo sapiens (human)",
          28
        ],
        [
          "Diabetic cardiomyopathy - Homo sapiens (human)",
          25
        ],
        [
          "Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)",
          25
        ],
        [
          "Non-alcoholic fatty liver disease - Homo sapiens (human)",
          21
        ],
        [
          "Nucleocytoplasmic transport - Homo sapiens (human)",
          19
        ],
        [
          "Proteasome - Homo sapiens (human)",
          13
        ],
        [
          "Spinocerebellar ataxia - Homo sapiens (human)",
          13
        ],
        [
          "Retrograde endocannabinoid signaling - Homo sapiens (human)",
          12
        ]
      ]
    },
    "L1_low": {
      "n_genes": 366,
      "top_features": [
        [
          "Metabolic pathways - Homo sapiens (human)",
          58
        ],
        [
          "Pathways in cancer - Homo sapiens (human)",
          35
        ],
        [
          "ATP-dependent chromatin remodeling - Homo sapiens (human)",
          23
        ],
        [
          "Human immunodeficiency virus 1 infection - Homo sapiens (human)",
          22
        ],
        [
          "Human papillomavirus infection - Homo sapiens (human)",
          22
        ],
        [
          "Aminoacyl-tRNA biosynthesis - Homo sapiens (human)",
          21
        ],
        [
          "Cadherin signaling - Homo sapiens (human)",
          21
        ],
        [
          "Cellular senescence - Homo sapiens (human)",
          20
        ],
        [
          "PI3K-Akt signaling pathway - Homo sapiens (human)",
          19
        ],
        [
          "Human T-cell leukemia virus 1 infection - Homo sapiens (human)",
          18
        ],
        [
          "Salmonella infection - Homo sapiens (human)",
          18
        ],
        [
          "Thyroid hormone signaling pathway - Homo sapiens (human)",
          17
        ],
        [
          "Homologous recombination - Homo sapiens (human)",
          17
        ],
        [
          "Protein processing in endoplasmic reticulum - Homo sapiens (human)",
          17
        ],
        [
          "Herpes simplex virus 1 infection - Homo sapiens (human)",
          17
        ],
        [
          "Proteoglycans in cancer - Homo sapiens (human)",
          17
        ],
        [
          "Regulation of actin cytoskeleton - Homo sapiens (human)",
          16
        ],
        [
          "IgSF CAM signaling - Homo sapiens (human)",
          16
        ],
        [
          "mTOR signaling pathway - Homo sapiens (human)",
          16
        ],
        [
          "Adrenergic signaling in cardiomyocytes - Homo sapiens (human)",
          15
        ]
      ]
    },
    "L0_no_annotation": {
      "n_genes": 780,
      "top_features": []
    }
  }
}